International Journal of Applied Pharmaceutics
Vol 1 Issue 1, 2009
PREPARATION AND IN VITRO CHARACTERISTICS OF TABLET CORES COATED WITH ALBIZIA, ALBIZIA/KHAYA AND ALBIZIA/HPMC FILMS
KWABENA OFORI-KWAKYE*, EMILY NAA NORLEY ADOM, AND SAMUEL LUGRIE KIPO
Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
This study was carried out to assess the in vitro behaviour of tablet cores coated with novel films of albizia, albizia/khaya and albizia/HPMC. Diclofenac sodium tablet cores, ~ 225 mg, were formulated and coated with aqueous film formulations consisting of albizia gum only, albizia/khaya (25:75), and albizia/HPMC (90:10). The thickness, breaking strength, disintegration time, swelling index and drug release properties of the uncoated and film coated tablets were evaluated. Tablet thickness increased with increase in coating time. The breaking strength of the film coated tablets was higher than that of the tablet cores and increased with increase in coating time. The disintegration time of the uncoated and film coated tablets in the media used was pH-dependent and followed the rank order: 0.1 M HCl > pH 6.8 phosphate buffer > distilled water. The extent of swelling (water absorption) of the film coated tablets in 0.1 M HCl was dependent on film composition and followed the order: albizia/HPMC > albizia > albizia/khaya. Drug release in pH 6.8 phosphate buffer was faster than in 0.1 M HCl solution. Albizia and albizia/HPMC film coated tablets exhibited the slowest drug release in the acidic and basic media, respectively. The study shows the potential of albizia, albizia/khaya and albizia/HPMC films as coating materials for tablets.
KEYWORDS: Albizia gum, khaya gum, aqueous film coating, disintegration of film coated tablets, drug release properties
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