International Journal of Applied Pharmaceutics

Vol 1 Issue 1, 2009

 

 

 

TABLETING COMPRESSION BEHAVIOUR OF ENZYME TRYPSIN-CHYMOTRYPSIN

KSHIRSAGAR, R.V.* 1, TADAVI, S.A.1, PAWDE, P.K.1, R. RAJAN 2

1School of pharmacy, Swami Ramanand Teerth Marathwada University Nanded-431 606(M.S.) India.

2Elder pharmaceuticals Pvt. Ltd. Navi Mumbai- 400706 (M.S.) India

Email: rajksagar53@rediffmail.com

 

ABSTRACT

Main purpose of the study was compaction, compression behavior and enteric coating properties of enzyme. Compression behavior of different excipient and drug diffusion properties of enteric coated tablet were study using dissolution study. Trypsin chymotrypsin was used as a model drug for formulation of tablet. Tablet were prepared with starch and lactose at a different compression pressure of 7, 8, 9, 10 KPa of four batches of each. And tablet was coated with Ethylcellulose as a coating polymer dispersed in organic solvent such as dichloromethane. The coating formulation was based on Ethylcellulose and diethyl phthalate as plasticizer this innovation evidently prevented the premature drug migration from the core into the enteric coat layer. Ethylcellulose as a coating material can prevent the influx of the dissolution medium into the tablet core, and thus decrease the premature dissolution and release of the drug from the enteric-coated tablet in 0.1 N HCl solutions. The compression behavior of tablet with different excipient can be study using a dissolution study. As increases pressure decreases enzymatic activity.

Keywords: Drug release; tablet Coating; Compression pressure, KPa.

 


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